After a series of choices the player can pick four endings to conclude David's nightmarish tale. Arming himself with a knife, handgun, and a shotgun, David ventures down into parking lot and sewers, blasting his way through armies of monsters, and is chased by the police into a forest. He wakes up hours later, and finds that it's night and the hospital is closed, almost pitch black, and overrun abominable and hostile creatures known as Twitchers.
In the bathroom, he finds a bottle of pain-killers and takes them, sending him into a drug-induced nightmare. Afraid of Monsters: Director's Cut focuses on the troubled and drug-addicted David Leatherhoff who heads to Markland Hospital for rehab to fight his addiction against a mysterious drug.